NADH or Nicortinamide adenine dinucleotide is a coenzyme derived from vitamin B2 or niacin. It is found in all living cells. As a coenzyme, it helps enzymes do their functions. Enzymes are proteins that work as a catalyst in the body to prompt chemical changes in other substances. Coenzymes are mostly synthesized from vitamins and needed by the body for optimum energy production. NADH stimulates production of ATP (adenosine triphosphate) which is a compound that regulates the release of energy stored in cells. More NADH in a cell means more chemical energy it produces. Increased concentrations of NADH in the brain boost the production of neurotransmitters brain chemicals necessary for sound mental function. NADH used to be administered intravenously because the stomach acid rapidly destroys the delicate molecule. Recently, the supplement comes in new enteric-coated, oral tablet form.
These are the specific benefits of taking NADH supplements:
NADH supplements combat from simple fatigue to chronic fatigue syndrome and fibromyalgia. Studies are currently conducted to determine the value of NADH supplements in improving mental function in Alzheimer's disease and reducing physical disability and relieving depression in people with Parkinson's disease.
NADH supplements are taken in by healthy individuals to improve concentration and memory capacity as well for athletic endurance. Although as of now there are no published studies that indicate the effectiveness of NADH for these purposes.
NADH is found to relieve chronic fatigue syndrome in a recent study by FDA. NADH also relieves general fatigue including fibromyalgia-related exhaustion because it increases energy in cells thereby boosting energy in people with fibromyalgia. Fibromyalgia is a disorder causing muscle pain and fatigue.
NADH relieves depression by stimulating production of a number of key chemicals called neurotransmitters which could alleviate depression.
NADH is also known to assist in Parkinson's therapy because it increases the levels of dopamine which slows down physical symptoms of Parkinson's disease and the accompanying depression.
NADH also improves Alzheimer's symptoms by improving cognitive dysfunction.
NADH is distributed in tablet form. It is best to take it with water on an empty stomach. There is no known drug or nutrient interactions related with NADH. High doses or about 10 mg or more a day can cause jitteriness, anxiety and insomnia. Safety of long-term treatment of oral NADH could not be ascertained. But use for no longer than four months before starting again a month after is recommended. Or you can take it two or three time per week instead of daily.
To prevent side effects such as jitteriness and mild overstimulation, begin with small oral dose of about 2.5 mg per day for several weeks then increase the dosage over a period of two to three weeks. For chronic fatigue syndrome and simple fatigue, take 2.5 mg twice daily for 10 days then 5 mg twice daily. For fibromyalgia, take 2.5 mg twice daily for 14 days then 5 mg twice daily. For Parkinson's disease, take 5 mg a day, increasing it to over two weeks to 10 mg twice a day. For Alzheimer's disease, take 5 mg a day.
Written by:
G. Metcalf
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